南京大学，生命科学学院，教授

从事炎症性肠病及肠炎诱发的癌症等相关疾病的发病机制探讨及治疗策略研究，阐明特定免疫细胞种群中的关键蛋白及非编码核酸在肠道炎性疾病过程中的重要作用；并以上述关键细胞和分子作为靶点，开展治疗研究，取得很好疗效，以第一作者和通讯作者发表论文20余篇，包括胃肠病学和生物治疗领域的重要期刊Gut，Mucosal Immunology和Molecular Therapy等，主持国家自然科学基金项目3项。

教育经历：

2008-09至2013-06，南京大学，生命科学学院，博士，导师：张峻峰

2004-09至2008-06，南京大学，生命科学学院，学士

研究工作经历：

2022-01至现在，   南京大学，生命科学学院，教授

2015-09至2021-12，南京大学，生命科学学院，副教授

2013-07至2015-08，南京大学，生命科学学院，博士后

 炎症性肠炎及肠病发病机制研究

[1] Chen Wang, Ziyu Shi, Yuqian Zhang, Mingyue Li , Jie Zhu, Zhen Huang*, Junfeng Zhang*, Jiangning Chen*. CBFβ promotes colorectal cancer progression through transcriptionally activating OPN, FAM129A, and UPP1 in a RUNX2-dependent manner. Cell Death Differ. 2021;28(11):3176-3192.     

[2] Fu Yong, Ni Junjun, Chen Jiahui, Ma Gailing, Zhao Mingming, Zhu Shuaidong, Shi Tongguo, Zhu Jie, Huang Zhen*, Zhang Junfeng*, Chen Jiangning*. Dual-Functionalized MSCs that Express CX3CR1 and IL-25 Exhibit Enhanced Therapeutic Effects on Inflammatory Bowel Disease. Mol Ther. 28:1214-1228, 2020.   

[3] Hu Junqing, Xu Jinhao, Li Mingyue, Zhang Yanping, Yi Huaiqiang, Chen Jiangning, Dong Lei, Zhang Junfeng, Huang Zhen. Targeting Lymph Node Sinus Macrophages to Inhibit Lymph Node Metastasis. Mol Ther Nucleic Acids. 2019 Jun 7;16:650-662.  

[4] Ma Junting, Yang Yaping, Fu Yong, Guo Feilong, Zhang Xiaoyi, Xiao Shuke, Zhu Weiming, Huang Zhen*, Zhang Junfeng, Chen Jiangning. PIAS3-mediated feedback loops promote chronic colitis-associated malignant transformation. Theranostics. 8:3022-3037, 2018. 

[5] Tu Tingyue, Yu Mao, Zhang Yanping, Shi Xiafei, Xu Jinhao, Hu Junqing, Gan Jingjing, He Wei, Dong Lei, Han Jianlin, Huang Zhen*, Pan Yi, Zhang Junfeng. A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway. Biochem Pharmacol. 155:275-287, 2018.   

[6] Fu Yong, Ma Junting, Shi Xiafei, Yang Yaping, Xiao Shuke, Li Jiahuang, Huang Zhen*, Zhang Junfeng, Chen Jiangning. A novel pyrazole-containing indolizine derivative suppresses NF-kappa B activation and protects against TNBS-induced colitis via a PPAR-gamma-dependent pathway. Biochem Pharmacol. 135: 126-138, 2017. 

[7] Shi Tongguo, Xie Yin, Fu Yong, Zhou Qian, Ma Zirong, Ma Junting, Huang Zhen*, Zhang Junfeng, Chen Jiangning. The signaling axis of microRNA-31/interleukin-25 regulates Th1/Th17-mediated inflammation response in colitis. Mucosal Immunol. 10: 983-995, 2017.

[8] Huang Zhen, Gan Jingjing, Long Ziyan, Guo Gguangxing, Shi Xiafei, Wang Chunming, Zang Yuhui, Ding Zhi, Chen Jiangning, Zhang Junfeng, Dong Lei. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection. Biomaterials. 90:72-84, 2016.   

[9] Ding Haixia#, Huang Zhen#, Chen Mengjie, Wang Cheng, Chen Xi, Chen Jianing, Zhang Junfeng. Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease. Parkinsonism Relat Disord. 22:68-73, 2016.  

[10] Huang Zhen, Ma Junting, Chen Mengjie, Jiang Haoyang, Fu Yong, Gan Jingjing, Dong Lei, Zhang Junfeng, Chen Jiangning. Dual TNF-alpha/IL-12p40 Interference as a Strategy to Protect Against Colitis Based on miR-16 Precursors With Macrophage Targeting Vectors. Mol Ther. 23:1611-21, 2015.   

[11] Huang Zhen，Gan Jingjing, Jia Lixin, Guo Guangxing, Wang Chunming, Ding Zhi, Zang Yuhui, Chen Jiangning, Dong Lei, Junfeng Zhang. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials. 48:26-36, 2015.   

[12] Wang Zhenheng#, Huang Zhen#, Gan Jingjing, Liu Naicheng, Zhou Gang, Shi Tongguo, Wang Zhenzhen, Wang Rrui, Bao Nirong, Guo Ting, Chen Jiangning, Zhang Junfeng, Dong Lei, Zhao Jianing. The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s. Acta Biomater. 24:352-60, 2015. 

[13] Huang Zhen, Shi Tongguo, Zhou Qian, Shi Song, Zhao Ran, Shi Hao, Dong Lei, Chenyu Zhang, Zeng Ke, Chen Jiangning, Zhang Junfeng. MiR-141 Regulates colonic leukocytic trafficking by targeting CXCL12beta during murine colitis and human Crohn's disease. Gut. 63:1247-57, 2014.    

[14] Huang Zhen, Wang Zhenzhen, Long Shanshan, Jiang Haoyang, Chen Jiangning, Zhang Junfeng, Dong Lei. 3-D Artificial Colon Tissue Mimic for the Evaluation of Nanoparticle-Based Drug Delivery System. Mol Pharm. 11:2051-61,2014.  

[15] Huang Zhen, Yang Yang, Jiang Yucui, Shao Juan, Sun Xulun, Chen Jiangning, Dong Lei, Junfeng Zhang. Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers. Biomaterials. 34:746-55,2013.

[16] Huang Zhen, Jiang Yuicui, Yang Yang, Shao Juan, Sun Xulun, Chen Jiangning, Dong Lei, Zhang Junfeng. 3, 3’-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction. Mol Immunol. 53:335-44,2013.

[17] Huang Zhen, Zhang Zhengping, Zha Yinhe, Liu Jialing, Jiang Yuicui,  Yang Yang, Shao Juan, Sun Xulun, Yin Yuan, Cai Xin, Chen Jiangning, Dong Lei, Zhang Junfeng. The effect of targeted delivery of anti-TNF-alpha oligonucleotide into CD169+ macrophages on disease progression in lupus-prone MRL/lpr mice. Biomaterials. 33:7605-12,2012.

[18] Huang Zhen, Zhang Zhengping, Jiang Yucui, Zhang Dachuan, Chen Jiangning, Dong Lei, Zhang Junfeng. Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy. J Control Release. 158:286-92,2012.

[19] Huang Zhen, Dong Lei, Chen Jijun, Gao Fengbo, Zhang Zhengping, Chen Jiangning, Zhang Junfeng. Low-molecular weight chitosan/vascular endothelial growth factor short hairpin RNA for the treatment of hepatocellular carcinoma. Life Sci. 91:1207-15, 2012.

[20] Huang Zhen, Zuo Longsheng, Zhang Zhengping, Liu Jialing, Chen Jiangning, Dong Lei, Zhang Junfeng. 3, 3’-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway. Free Radic Biol Med. 50:228-36, 2011.

[21] Ding Haixia#, Huang Zhen#, Chen Mengjie, Wang Cheng, Chen Xi, Chen Jianing, Zhang Junfeng. Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease. Parkinsonism Relat Disord. 22:68-73, 2016.   

[22] Wang Zhenheng#, Huang Zhen#, Gan Jingjing, Liu Naicheng, Zhou Gang, Shi Tongguo, Wang Zhenzhen, Wang Rrui, Bao Nirong, Guo Ting, Chen Jiangning, Zhang Junfeng, Dong Lei, Zhao Jianing. The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s. Acta Biomater. 24:352-60, 2015.