长期从事生物材料领域研究，内容主要涉及生物材料的生物学效应、组织工程与再生医学等方向。目前的研究重点是生物材料与细胞的相互作用界面，主要研究生物材料与生理环境中细胞的相互作用方式及原理，基于此，开发可增强或增加细胞对环境因素响应能力的新型生物材料技术，为未来先进材料与生物系统的深度融合提供新的技术和理论，尝试整合生物材料与生物系统相互作用的精确控制，在体内模拟肿瘤微环境，塑造新的器官，实现组织工程器官再生的新突破。

教育及工作经历

1999–2003 南京大学生命科学学院  学士（生物技术）

2003–2007 南京大学生命科学学院  博士（生物化学与分子生物学）

2007–2009 南京大学化学化工学院  博士后（高分子）

2010–2012 南京大学生命科学学院  副教授

2013–至今 南京大学生命科学学院  教授

2022-至今 无锡市南京大学锡山应用生物技术研究所 所长，研究员

获奖情况

2021年荣获“长江学者奖励计划”特聘教授

2017年荣获江苏省杰出青年科学基金资助

2014年入选教育部“新世纪优秀人才支持计划”

再生医学

1. 国家自然科学基金委员会，国际(地区)合作与交流项目，32230056，复杂器官与组织在脾脏内的功能性再生，2023-2027，272 万元，主持；

2. 国家自然科学基金委员会，国际(地区)合作与交流项目，31961160701，设计可重塑组织微环境的生物材料支持异种肝组织的脾脏内再生，2020-2022，132 万元，主持；

3. 国家自然科学基金委员会，面上项目，81973273，蛋白冠状物介导可吸入颗粒物促进肺癌发生的活性机制研究，2020-2023，59万，主持；

4. 国家自然科学基金委员会，面上项目，81673380，蛋白冠状物在SiO2纳米微粒诱发矽肺病过程中的作用机制研究，2017-2020，62万，结题、主持；

5. 江苏省自然科学基金委员会，杰出青年基金项目，BK20170015，基于蛋白冠状物的核酸药物递释系统与机体相互作用研究，100万，2017-2020，结题、主持；

6. 教育部“新世纪优秀人才支持计划”，2014-2016，50万元，结题、主持；

7. 国家自然科学基金面上项目，阳离子聚合物特异性活化Th1免疫反应用于肿瘤的免疫治疗研究，2013-2016，80万元，结题、主持；

南京大学“登峰人才支持计划”，2013-2016，100万元，结题、主持。

1 Wang Zhenzhen, Zhai Ziyu, Chen Chunyu, Tian Xuejiao, Xing Zhen, Xing Panfei, Yang Yushun, Zhang Junfeng, Wang Chunming & Dong Lei. Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer. Elife 11, doi:10.7554/eLife.75345 (2022).

2  Liu Chunyan, Wang Lintao, Xu Mengzhen, Sun Yajie, Xing Zhen, Zhang Junfeng, Wang Chunming & Dong Lei. Reprogramming the spleen into a functioning 'liver' in vivo. Gut, doi:10.1136/gutjnl-2021-325018 (2022).

3  Wang Yulian, Pang Jiayun, Wang Qingyun, Yan Luocheng, Wang Lintao, Xing Zhen, Wang Chunming, Zhang Junfeng & Dong Lei. Delivering Antisense Oligonucleotides across the Blood‐Brain Barrier by Tumor Cell‐Derived Small Apoptotic Bodies. Advanced Science, doi:10.1002/advs.202004929 (2021).

4  Sun X., Xiang J., Chen R., Geng Z., Wang L., Liu Y., Ji S., Chen H., Li Y., Zhang C., Liu P., Yue T., Dong L. & Fu X. Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin. Adv Sci (Weinh) 8, e2103079, doi:10.1002/advs.202103079 (2021).

5  Niu Y. M., Wang Z. Z., Shi Y. C., Dong L. & Wang C. M. Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches. Bioactive Materials 6, 244-261, doi:10.1016/j.bioactmat.2020.08.012 (2021).

6  Mu Ruoyu, Zhang Yuhan, Yan Lingli, Liao Zhencheng, Yang Yushun, Su Huanxing, Dong Lei & Wang Chunming. A "Bridge-Building" Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization. Advanced materials (Deerfield Beach, Fla.) 33, e2103490, doi:10.1002/adma.202103490 (2021).

7  Liu Shang, Wang Zhenzhen, Jiang Xinbang, Gan Jingjing, Tian Xuejiao, Xing Zhen, Yan Yiqing, Chen Jiahui, Zhang Junfeng, Wang Chunming & Dong Lei. Denatured corona proteins mediate the intracellular bioactivities of nanoparticles via the unfolded protein response. Biomaterials 265, 120452, doi:10.1016/j.biomaterials.2020.120452 (2021).

8  Li Yurong, Wang Shaocong, Xing Zhen, Niu Yiming, Liao Zhencheng, Lu Yang, Qiu Junni, Zhang Junfeng, Wang Chunming & Dong Lei. Destructing biofilms by cationic dextran through phase transition. Carbohydrate Polymers, 118778, doi:https://doi.org/10.1016/j.carbpol.2021.118778 (2021).

9  Han Congwei, Song Jinji, Hu Junqing, Fu Huijie, Feng Yanxian, Mu Ruoyu, Xing Zhen, Wang Zhenzhen, Wang Lintao, Zhang Junfeng, Wang Chunming & Dong Lei. Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy. Cell Rep 34, 108706, doi:10.1016/j.celrep.2021.108706 (2021).

10  Xing Panfei, Niu Yiming, Mu Ruoyu, Wang Zhenzhen, Xie Daping, Li Huanling, Dong Lei & Wang Chunming. A pocket-escaping design to prevent the common interference with near-infrared fluorescent probes in vivo. Nature Communications 11, doi:10.1038/s41467-020-15323-8 (2020).

11  Wang Zhenzhen, Niu Yiming, Tian Xuejiao, Yu Na, Yin Xiaoyu, Xing Zhen, Li Yurong, Dong Lei & Wang Chunming. Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis. Advanced Functional Materials, 2007408, doi:10.1002/adfm.202007408 (2020).

12  Wang Lintao, Wang Chunming, Wang Zhenzhen, Gan Jingjing, Liu Chunyan, Xia Suhua, Niu Yiming, Chen Dianhau, Zhang Junfeng & Dong Lei. Transforming the spleen into a liver-like organ in vivo. Sci Adv 6, eaaz9974, doi:ARTN eaaz9974

10.1126/sciadv.aaz9974 (2020).

13  Wang Chenqi, Deng Jia, Deng Hao, Kang Zhiqian, Huang Zhen, Ding Zhi, Dong Lei, Chen Jiangning, Junfeng Zhang & Zang Yuhui. A novel Sox9/lncRNA H19 axis contributes to hepatocyte death and liver fibrosis. Toxicological Sciences, doi:10.1093/toxsci/kfaa097 (2020).

14  Niu Y. M., Wang L. T., Yu N., Xing P. F., Wang Z. Z., Zhong Z. F., Feng Y. X., Dong L. & Wang C. M. An "all-in-one" scaffold targeting macrophages to direct endogenous bone repair in situ. Acta Biomaterialia 111, 153-169, doi:10.1016/j.actbio.2020.05.023 (2020).

15  Niu Yiming, Zhang Yuhan, He Wei, Xing Panfei, Dong Lei, Li Qiu & Wang Chunming. Engineering a microcarrier based on a polysaccharide-growth factor complex for enhancing the proliferation of mesenchymal stem cells. International Journal of Biological Macromolecules 155, 911-918, doi:10.1016/j.ijbiomac.2019.11.049 (2020).

16  Liu S., Jiang X., Tian X., Wang Z., Xing Z., Chen J., Zhang J., Wang C. & Dong L. A method to measure the denatured proteins in the corona of nanoparticles based on the specific adsorption of Hsp90ab1. Nanoscale 12, 15857-15868, doi:10.1039/d0nr02297g (2020).

17  He Wei, Xu Jinzhi, Mu Ruoyu, Li Qiu, Lv Da-lun, Huang Zhen, Zhang Junfeng, Wang Chunming & Dong Lei. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation. Nat Commun 11, 1732, doi:10.1038/s41467-020-15524-1 (2020).

18  Chen Yu, Qian Baowei, Sun Xiaolin, Kang Zhiqian, Huang Zhen, Ding Zhi, Dong Lei, Chen Jiangning, Zhang Junfeng & Zang Yuhui. Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma. Cancer letters, doi:10.1016/j.canlet.2020.11.025 (2020).

19  Chen Q., Zhang F., Dong L., Wu H. M., Xu J., Li H. Q., Wang J., Zhou Z., Liu C. Y., Wang Y. B., Liu Y. Y., Lu L. S., Wang C., Liu M. H., Chen X., Wang C., Zhang C. N., Li D. S., Zen K., Wang F. Y., Zhang Q. P. & Zhang C. Y. SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Cell Research, doi:10.1038/s41422-020-0389-3 (2020).

20  Wang Zhenzhen, Rui Xiaying, Qiu Junni, Yan Yiqing, Gan Jingjing, Liu Shang, Wang Lintao, Zhang Junfeng, Wang Chunming & Dong Lei. Growing Trans-Species Islets in Tumor Extract-Remodeled Testicles. Advanced Science 6, 1801694, doi:10.1002/advs.201801694 (2019).

21  Niu Y. M., Li Q., Ding Y., Dong L. & Wang C. M. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Advanced drug delivery reviews 146, 190-208, doi:10.1016/j.addr.2018.06.002 (2019).

22  Li H. N., Shao F., Qian B. W., Sun Y. Y., Huang Z., Ding Z., Dong L., Chen J. N., Zhang J. F. & Zang Y. H. Upregulation of HER2 in tubular epithelial cell drives fibroblast activation and renal fibrosis. Kidney Int 96, 674-688, doi:10.1016/j.kint.2019.04.012 (2019).

23  Gan Jingjing, Liu Chunyan, Li Huanling, Wang Shaocong, Wang Zhenzhen, Kang Zhiqian, Huang Zhen, Zhang Junfeng, Wang Chunming, Lv Dalun & Dong Lei. Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors. Biomaterials 219, 119340, doi:10.1016/j.biomaterials.2019.119340 (2019).

24  Feng Yanxian, Mu Ruoyu, Wang Zhenzhen, Xing Panfei, Zhang Junfeng, Dong Lei & Wang Chunming. A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages. Nature Communications 10, 2272, doi:10.1038/s41467-019-10354-2 (2019).

25  Xing P. F., Zhang Z., Niu Y. M., Qi Y. N., Dong L. & Wang C. M. Water solubility is essential for fluorescent probes to image hypochlorous acid in live cells. Chemical Communications 54, doi:10.1039/c8cc04631j (2018).

26  Xing P. F., Shi Y. C., Li Q., Feng Y. X., Dong L. & Wang C. M. An ortho-aldehyde modified probe to image thiols in living cells with enhanced selectivity. Talanta 179, 326-330, doi:10.1016/j.talanta.2017.11.035 (2018).

27  Xing P. F., Feng Y. X., Niu Y. M., Li Q., Zhang Z., Dong L. & Wang C. M. A Water-Soluble, Two-Photon Probe for Imaging Endogenous Hypochlorous Acid in Live Tissue. Chem-Eur J 24, 5748-5753, doi:10.1002/chem.201800249 (2018).

28  Wang Zhenzhen, Wang Chunming, Abudukeremu Ayipaxia, Rui Xiaying, Liu Shang, Zhang Xiaoyi, Zhang Min, Zhang Junfeng & Dong Lei. Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells. Advanced Science 5, 1700666, doi:10.1002/advs.201700666 (2018).

29  Wang Chunming, Wang Zhenzhen & Dong Lei. Translating Current Bioanalytical Techniques for Studying Corona Activity. Trends in Biotechnology 36, 661-672, doi:10.1016/j.tibtech.2018.02.016 (2018).

30  Tu Tingyue, Yu Mao, Zhang Yanping, Shi Xiafei, Xu Jinhao, Hu Junqing, Gan Jingjing, He Wei, Dong Lei, Han Jianlin, Huang Zhen, Pan Yi & Zhang Junfeng. A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway. Biochemical Pharmacology 155, 275-287, doi:10.1016/j.bcp.2018.07.020 (2018).

31  Shi Yuchen, Wang Lintao, Niu Yiming, Yu Na, Xing Panfei, Dong Lei & Wang Chunming. Fungal Component Coating Enhances Titanium Implant-Bone Integration. Advanced Functional Materials 28, doi:10.1002/adfm.201804483 (2018).

32  Li Huanan, Cai Huimin, Deng Jia, Tu Xiaolong, Sun Yanyan, Huang Zhen, Ding Zhi, Dong Lei, Chen Jiangning, Zang Yuhui & Zhang Junfeng. TGF-beta-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis. Biochimica Et Biophysica Acta-Molecular Basis of Disease 1864, 520-532, doi:10.1016/j.bbadis.2017.11.011 (2018).

33  Gan J. J., Dou Y. Y., Li Y. R., Wang Z. Z., Wang L. T., Liu S., Li Q., Yu H. R., Liu C. Y., Han C. W., Huang Z., Zhang J. F., Wang C. M. & Dong L. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials 178, 95-108, doi:10.1016/j.biomaterials.2018.06.015 (2018).

34  Wang Zhenzhen, Wang Chunming, Liu Shang, He Wei, Wang Lintao, Gan Jingling, Huang Zhen, Wang Zhenheng, Wei Haoyang, Zhang Junfeng & Dong Lei. Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor beta 1 Activity in Triggering Lung Fibrosis. Acs Nano 11, 1659-1672, doi:10.1021/acsnano.6b07461 (2017).

35  Wang Z., Deng Z., Gan J., Zhou G., Shi T., Wang Z., Huang Z., Qian H., Bao N., Guo T., Chen J., Zhang J., Liu F., Dong L. & Zhao J. TiAl6V4 particles promote osteoclast formation via autophagy-mediated downregulation of interferon-beta in osteocytes. Acta Biomater 48, 489-498, doi:10.1016/j.actbio.2016.11.020 (2017).

36  Wang Y., Guo G., Feng Y., Long H., Ma D. L., Leung C. H., Dong L. & Wang C. A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages (TAMs). J Mater Chem B 5, 7307-7318, doi:10.1039/c7tb01495c (2017).

37  Tu Xiaolong, Zhang Yuanyuan, Zheng Xiuxiu, Deng Jia, Li Huanan, Kang Zhiqian, Cao Zhipeng, Huang Zhen, Ding Zhi, Dong Lei, Chen Jiangning, Zang Yuhui & Zhang Junfeng. TGF-beta-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice. Scientific Reports 7, doi:10.1038/s41598-017-03175-0 (2017).

38  Sun Xiaolin, Zhao Shuhua, Li Huanan, Chang Hanwen, Huang Zhen, Ding Zhi, Dong Lei, Chen Jiangning, Zang Yuhui & Zhang Junfeng. MicroRNA-30b Suppresses Epithelial-Mesenchymal Transition and Metastasis of Hepatoma Cells. Journal of Cellular Physiology 232, 625-634, doi:10.1002/jcp.25466 (2017).

39  Niu Yiming, Li Qiu, Xie Ruiyu, Liu Shang, Wang Ruibing, Xing Panfei, Shi Yuchen, Wang Yitao, Dong Lei & Wang Chunming. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material. Biomaterials 139, 39-55, doi:10.1016/j.biomaterials.2017.05.042 (2017).

40  Li Qiu, Niu Yiming, Diao Huajia, Wang Lintao, Chen Xiuping, Wang Yitao, Dong Lei & Wang Chunming. In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials 148, 54-68, doi:10.1016/j.biomaterials.2017.09.028 (2017).

41  Li Qiu, Feng Yanxian, He Wei, Wang Lintao, Wang Ruibing, Dong Lei & Wang Chunming. Post-screening characterisation and in viva evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides. Carbohydrate Polymers 169, 304-314, doi:10.1016/j.carbpol.2017.04.034 (2017).

42  He Wei, Zhu Yi, Mu Ruoyu, Xu Jinzhi, Zhang Xiaoyi, Wang Chunming, Li Qiu, Huang Zhen, Zhang Junfeng, Pan Yi, Han Jianlin & Dong Lei. A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for cancer immunotherapy. Biochemical Pharmacology 145, 132-146, doi:10.1016/j.bcp.2017.08.019 (2017).

43  He Wei, Wang Chen, Mu Ruoyu, Liang Pei, Huang Zhen, Zhang Junfeng & Dong Lei. MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. Oncogene 36, 4212-4223, doi:10.1038/onc.2017.62 (2017).

44  Feng Yanxian, Li Qiu, Wu Dang, Niu Yiming, Yang Cheng, Dong Lei & Wang Chunming. A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis. Biomaterials 134, 128-142, doi:10.1016/j.biomaterials.2017.04.042 (2017).

45  Chan Weng- I., Zhang Guangpan, Li Xin, Leung Chung-Hang, Ma Dik-Lung, Dong Lei & Wang Chumming. Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immuno-active biomaterials. Biomaterials Science 5, 403-407, doi:10.1039/c6bm00799f (2017).

46  Zhu Q., Qi H., Long Z., Liu S., Huang Z., Zhang J., Wang C. & Dong L. Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy. Scientific Reports 6, 28596 (2016).

47  Wang Lintao, Chen Qian, Qi Haixia, Wang Chunming, Wang Cheng, Zhang Junfeng & Dong Lei. Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage. Cancer Research 76, 6631-6642, doi:10.1158/0008-5472.can-15-3034 (2016).

48  Li Qiu, Guo Guanwing, Meng Fancheng, Wang Helena H., Niu Yiming, Zhang Qingwen, Zhang Junfeng, Wang Yitao, Dong Lei & Wang Chunming. A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis. Acs Macro Letters 5, 617-621, doi:10.1021/acsmacrolett.6b00182 (2016).

49  Huang Zhen, Gan Jingjing, Long Ziyan, Guo Guangxing, Shi Xiafei, Wang Chunming, Zang Yuhui, Ding Zhi, Chen Jiangning, Zhang Junfeng & Dong Lei. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection. Biomaterials 90, 72-84, doi:10.1016/j.biomaterials.2016.03.009 (2016).

50  He Wei, Liang Pei, Guo Guangxing, Huang Zhen, Niu Yiming, Dong Lei, Wang Chunming & Zhang Junfeng. Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy. Scientific Reports 6, doi:10.1038/srep24506 (2016).

51  Zhou Zhen, Li Xihan, Liu Jinxiong, Dong Lei, Chen Qun, Liu Jialing, Kong Huihui, Zhang Qianyi, Qi Xian, Hou Dongxia, Zhang Lin, Zhang Guoquan, Liu Yuchen, Zhang Yujing, Li Jing, Wang Jin, Chen Xi, Wang Hua, Zhang Junfeng, Chen Hualan, Zen Ke & Zhang Chen-Yu. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Research 25, 39-49, doi:10.1038/cr.2014.130 (2015).

52  Zhang Zhengping, Wang Chunming, Zha Yinhe, Hu Wei, Gao Zhongfei, Zang Yuhui, Chen Jiangning, Zhang Junfeng & Dong Lei. Corona-Directed Nucleic Acid Delivery into Hepatic Stellate Cells for Liver Fibrosis Therapy. Acs Nano 9, 2405-2419, doi:10.1021/nn505166x (2015).

53  Wang Zhenheng, Liu Naicheng, Liu Kang, Zhou Gang, Gan Jingjing, Wang Zhenzhen, Shi Tongguo, He Wei, Wang Lintao, Guo Ting, Bao Nirong, Wang Rui, Huang Zhen, Chen Jiangning, Dong Lei, Zhao Jianning & Zhang Junfeng. Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis. Autophagy 11, 2358-2369, doi:10.1080/15548627.2015.1106779 (2015).

54  Wang Zhenheng, Huang Zhen, Gan Jingjing, Liu Naicheng, Zhou Gang, Shi Tongguo, Wang Zhenzhen, Wang Rui, Bao Nirong, Guo Ting, Chen Jiangning, Zhang Junfeng, Dong Lei & Zhao Jianning. The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s. Acta Biomaterialia 24, 352-360, doi:10.1016/j.actbio.2015.06.024 (2015).

55  Wang Chunming & Dong Lei. Exploring 'new' bioactivities of polymers at the nano-bio interface. Trends in Biotechnology 33, 10-14, doi:10.1016/j.tibtech.2014.11.002 (2015).

56  Niu Yiming, Chan Weng- I., Yu Na, Gan Jingjing, Dong Lei & Wang Chunming. APTES-modified nanosilica - but neither APTES nor nanosilica - inhibits endothelial cell growth via arrest of cell cycle at G1 phase. Journal of Biomaterials Applications 30, 608-617, doi:10.1177/0885328215598497 (2015).

57  Huang Zhen, Ma Junting, Chen Mengjie, Jiang Haoyang, Fu Yong, Gan Jingjing, Dong Lei, Zhang Junfeng & Chen Jiangning. Dual TNF-alpha/IL-12p40 Interference as a Strategy to Protect Against Colitis Based on miR-16 Precursors With Macrophage Targeting Vectors. Molecular Therapy 23, 1611-1621, doi:10.1038/mt.2015.111 (2015).

58  Huang Zhen, Gan Jingjing, Jia Lixin, Guo Guangxing, Wang Chunming, Zang Yuhui, Ding Zhi, Chen Jiangning, Zhang Junfeng & Dong Lei. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials 48, 26-36, doi:10.1016/j.biomaterials.2015.01.013 (2015).

59  He Wei, Qi Haixia, Dong Lei & Zhang Junfeng. Research advances in drug delivery system targeting immune system. Journal of China Pharmaceutical University 46, 513-520 (2015).

60  Zhu Qian, Jia Lixin, Gao Zhongfei, Wang Chunming, Jiang Haoyang, Zhang Junfeng & Dong Lei. A Tumor Environment Responsive Doxorubicin-Loaded Nanoparticle for Targeted Cancer Therapy. Molecular Pharmaceutics 11, 3269-3278, doi:10.1021/mp4007776 (2014).

61  Yin Yuan, Cai Xing, Chen Xi, Liang Hongwei, Zhang Yujing, Li Jing, Wang Zuoyun, Chen Xiulan, Zhang Wen, Yokoyama Seiji, Wang Cheng, Li Liang, Li Limin, Hou Dongxia, Dong Lei, Xu Tao, Hiroi Takachika, Yang Fuquan, Ji Hongbin, Zhang Junfeng, Zen Ke & Zhang Chen-Yu. Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Research 24, 1164-1180, doi:10.1038/cr.2014.121 (2014).

62  Tu Xiaolong, Zhang Haiyan, Zhang Jingcheng, Zhao Shuhua, Zheng Xiuxiu, Zhang Zhengping, Zhu Jie, Chen Jiangning, Dong Lei, Zang Yuhui & Zhang Junfeng. MicroRNA-101 suppresses liver fibrosis by targeting the TGF beta signalling pathway. Journal of Pathology 234, 46-59, doi:10.1002/path.4373 (2014).

63  Liu Guoyin, Wang Rui, Dong Lei, Zhang Junfeng & Zhao Jianning. Endoplasmic reticulum stress-induced apoptosis of osteoblasts within the osteolytic craniums. Chinese Journal of Tissue Engineering Research 18, 5257-5265 (2014).

64  Huang Zhen, Wang Zhenzhen, Long Shanshan, Jiang Haoyang, Chen Jiangning, Zhang Junfeng & Dong Lei. A 3-D Artificial Colon Tissue Mimic for the Evaluation of Nanoparticle-Based Drug Delivery System. Molecular Pharmaceutics 11, 2051-2061, doi:10.1021/mp400723j (2014).

65  Huang Zhen, Shi Tongguo, Zhou Qian, Shi Song, Zhao Ran, Shi Hao, Dong Lei, Zhang Chenyu, Zeng Ke, Chen Jiangning & Zhang Junfeng. miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12 beta during murine colitis and human Crohn's disease. Gut 63, 1247-1257, doi:10.1136/gutjnl-2012-304213 (2014).

66  Zhang Zhengping, Zha Yinhe, Hu Wei, Huang Zhen, Gao Zhongfei, Zang Yuhui, Chen Jiangning, Dong Lei & Zhang Junfeng. The Autoregulatory Feedback Loop of MicroRNA-21/Programmed Cell Death Protein 4/Activation Protein-1 (MiR-21/PDCD4/AP-1) as a Driving Force for Hepatic Fibrosis Development. Journal of Biological Chemistry 288, 37082-37093, doi:10.1074/jbc.M113.517953 (2013).

67  Zhang Zhengping, Gao Zhongfei, Hu Wei, Yin Shan, Wang Chunming, Zang Yuhui, Chen Jiangning, Zhang Junfeng & Dong Lei. 3,3 '-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. British Journal of Pharmacology 170, 649-660, doi:10.1111/bph.12323 (2013).

68  Yao Zhengwei, Hu Wei, Yin Shan, Huang Zhen, Zhu Qian, Chen Jiangning, Zang Yuhui, Dong Lei & Zhang Junfeng. 3,3 '-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway. Pharmacological Research 70, 139-146, doi:10.1016/j.phrs.2013.01.006 (2013).

69  Wang Rui, Wang Zhenheng, Ma Yutao, Liu Guoyin, Shi Hao, Chen Jiangning, Dong Lei, Zhao Jianning & Zhang Junfeng. Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening. Biomaterials 34, 2611-2623, doi:10.1016/j.biomaterials.2013.01.025 (2013).

70  Huang Zhen, Yang Yang, Jiang Yucui, Shao Juan, Sun Xulun, Chen Jiangning, Dong Lei & Zhang Junfeng. Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers. Biomaterials 34, 746-755, doi:10.1016/j.biomaterials.2012.09.062 (2013).

71  Huang Zhen, Jiang Yucui, Yang Yang, Shao Juan, Sun Xulun, Chen Jiangning, Dong Lei & Zhang Junfeng. 3,3 '-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction. Molecular Immunology 53, 335-344, doi:10.1016/j.molimm.2012.09.007 (2013).

72  Dong Lei & Wang Chunming. Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering. Trends in Biotechnology 31, 342-346, doi:10.1016/j.tibtech.2013.04.001 (2013).

73  Huang Zhen, Zhang Zhengping, Zha Yinhe, Liu Jialin, Jiang Yucui, Yang Yang, Shao Juan, Sun Xulun, Cai Xin, Yin Yuan, Chen Jiangning, Dong Lei & Zhang Junfeng. The effect of targeted delivery of anti-TNF-alpha oligonucleotide into CD169(+) macrophages on disease progression in lupus-prone MRL/lpr mice. Biomaterials 33, 7605-7612, doi:10.1016/j.biomaterials.2012.06.074 (2012).

74  Huang Zhen, Zhang Zhengping, Jiang Yucui, Zhang Dachuan, Chen Jiangning, Dong Lei & Zhang Junfeng. Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy. Journal of Controlled Release 158, 286-292, doi:10.1016/j.jconrel.2011.11.013 (2012).

75  Huang Zhen, Zuo Longsheng, Zhang Zhengping, Liu Jialin, Chen Jiangning, Dong Lei & Zhang Junfeng. 3,3 '-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway. Free Radical Biology and Medicine 50, 228-236, doi:10.1016/j.freeradbiomed.2010.10.703 (2011).

76  Dong Lei, Huang Zhen, Cai Xing, Xiang Jiawei, Zhu Yi-An, Wang Rui, Chen Jiangning & Zhang Junfeng. Localized Delivery of Antisense Oligonucleotides by Cationic Hydrogel Suppresses TNF-alpha Expression and Endotoxin-Induced Osteolysis. Pharmaceutical Research 28, 1349-1356, doi:10.1007/s11095-010-0334-0 (2011).

77  Chen Jiangning, Chen Huan, Li Pei, Diao Huajia, Zhu Shiyu, Dong Lei, Wang Rui, Guo Ting, Zhao Jianning & Zhang Junfeng. Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds. Biomaterials 32, 4793-4805, doi:10.1016/j.biomaterials.2011.03.041 (2011).

78  Zuo Longsheng, Huang Zhen, Dong Lei, Xu Lingqing, Zhu Yi'an, Zeng Ke, Zhang Chenyu, Chen Jiangning & Zhang Junfeng. Targeting delivery of anti-TNF alpha oligonucleotide into activated colonic macrophages protects against experimental colitis. Gut 59, 470-479, doi:10.1136/gut.2009.184556 (2010).

79  Luo Yi, Diao Huajia, Xia Suhua, Dong Lei, Chen Jiangning & Zhang Junfeng. A physiologically active polysaccharide hydrogel promotes wound healing. Journal of Biomedical Materials Research Part A 94A, 193-204, doi:10.1002/jbm.a.32711 (2010).

80  Dong Lei, Xia Suhua, Wu Ke, Huang Zhen, Chen Huan, Chen Jiangning & Zhang Junfeng. A pH/Enzyme-responsive tumor-specific delivery system for doxorubicin. Biomaterials 31, 6309-6316, doi:10.1016/j.biomaterials.2010.04.049 (2010).

81  Dong Lei, Xia Suhua, Gao Fengbo, Zhang Dachuan, Chen Jiangning & Zhang Junfeng. 3,3 '-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis. Biochemical Pharmacology 79, 715-721, doi:10.1016/j.bcp.2009.10.010 (2010).

82  Dong Lei, Xia Suhua, Chen Huan, Chen Jiangning & Zhang Junfeng. Anti-arthritis activity of cationic materials. Journal of Cellular and Molecular Medicine 14, 2015-2024, doi:10.1111/j.1582-4934.2009.00806.x (2010).

83  Chen Huan, Li Pei, Yin Yuan, Cai Xing, Huang Zhen, Chen Jiangning, Dong Lei & Zhang Junfeng. The promotion of type 1 T helper cell responses to cationic polymers in vivo via toll-like receptor-4 mediated IL-12 secretion. Biomaterials 31, 8172-8180, doi:10.1016/j.biomaterials.2010.07.056 (2010).

84  Rui Wang, Ting G. U. O., Xiao-feng Zeng, Li-wu Zhou, Lei Dong, Jun-feng Zhang & Jian-ning Zhao. In vivo and in vitro cartilage transfection by a non-viral gene delivery system. Chinese Journal of Orthopaedic Trauma 11, 951-955 (2009).

85  Rui Wang, Ting G. U. O., Xiao-feng Zeng, Li-wu Zhou, Lei Dong, Jun-feng Zhang & Jian-ning Zhao. A novel nanometer non-viral gene transfer system for cartilage defects. Chinese Journal of Trauma 25, 563-568 (2009).

86  Dong Lei, Zuo Longsheng, Ma Suhua, Gao Shuying, Zhang Chenyu, Chen Jiangning & Zhang Junfeng. Reduction of liver tumor necrosis factor-alpha expression by targeting delivery of antisense oligonucleotides into Kupffer cells protects rats from fulminant hepatitis. Journal of Gene Medicine 11, 229-239, doi:10.1002/jgm.1293 (2009).

87  Dong Lei, Xia Suhua, Luo Yi, Diao Huajia, Zhang Jiani, Chen Jiangning & Zhang Junfeng. Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-alpha. Journal of Controlled Release 134, 214-220, doi:10.1016/j.jconrel.2008.11.013 (2009).

88  Dong Lei, Xia Suhua, Chen Huan, Chen Jiangning & Zhang Junfeng. Spleen-specific suppression of TNF-alpha by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models. Biomaterials 30, 4416-4426, doi:10.1016/j.biomaterials.2009.04.045 (2009).

89  Diao Huajia, Wang Jinliang, Shen Chao, Xia Suhua, Guo Ting, Dong Lei, Zhang Chenyu, Chen Jiangning, Zhao Jianning & Zhang Junfeng. Improved Cartilage Regeneration Utilizing Mesenchymal Stem Cells in TGF-beta 1 Gene-Activated Scaffolds. Tissue Engineering Part A 15, 2687-2698, doi:10.1089/ten.tea.2008.0621 (2009).

90  Cheng Xiaoyun, Zhang Feng, Zhou Guangxin, Gao Shuying, Dong Lei, Jiang Wei, Ding Zhi, Chen Jiangning & Zhang Junfeng. DNA/chitosan nanocomplex as a novel drug carrier for doxorubicin. Drug Delivery 16, 135-144, doi:10.1080/10717540802605376 (2009).

91  Dong Lei, Wang Rui, Zhu Yi-an, Wang Chunming, Diao Huajia, Zhang Chenyu, Zhao Jianning & Zhang Junfeng. Antisense oligonucleotide targeting TNF-alpha can suppress Co-Cr-Mo particle-induced osteolysis. Journal of Orthopaedic Research 26, 1114-1120, doi:10.1002/jor.20607 (2008).

92  Dong Lei, Gao Shuying, Diao Huajia, Chen Jiangning & Zhang Junfeng. Galactosylated low molecular weight chitosan as a carrier delivering oligonucleotides to Kupffer cells instead of hepatocytes in vivo. Journal of Biomedical Materials Research Part A 84A, 777-784, doi:10.1002/jbm.a.31328 (2008).

93  Diao Huajia, Li Xin, Chen Jiangning, Luo Yi, Chen Xi, Dong Lei, Wang Chumming, Zhang Chenyu & Zhang Junfeng. Bletilla striata polysaccharide stimulates inducible nitric oxide synthase and proinflammatory cytokine expression in macrophages. Journal of Bioscience and Bioengineering 105, 85-89, doi:10.1263/jbb.105.85 (2008).

94  Wang C. M., Sun J. T., Luo Y., Xue W. H., Diao H. J., Dong L., Chen J. N. & Zhang J. F. A polysaccharide isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro. Biotechnology Letters 28, 539-543, doi:10.1007/s10529-006-0011-x (2006).

95  Wang Chun-ming, Dong Lei, Diao Hua-jia, Chen Jiang-ning & Zhang Jun-feng. Chitosan inhibits high glucose-induced peroxidation and monocytes adhesion to vascular endothelial cells. Zhongguo Yaolixue Tongbao 22, 1054-1058 (2006).