9000万年前，灵长类与啮齿类动物分道扬镳，在进化树上走向了不同的分支。如今，我们却仍然依赖啮齿类动物来模拟和理解人类自身。巨大的物种差异，导致基于小鼠等实验动物所设计和验证的药物，仅有不足一成最终通过临床测试。因此，李颜博士致力于利用通过嵌合人体基因、细胞、组织到免疫缺陷的小鼠模型中，构建新型人源化小鼠，从而跨越物种障碍直接在小鼠中揭示人类疾病发生规律，以及开发相应的治疗手段。

教育及工作简历

2012-2015，法国国家健康与医学研究院，1223室，博士后

2015-2016，法国巴斯德研究所，免疫系，合同研究员

2016-2018，法国巴斯德研究所，免疫系，助理研究员

2018至今，南京大学，医学院模式动物研究所，教授/博导

2023至今，南京大学，医学院模式动物研究所，所长

获奖情况

2023 “南京大学青年五四奖章”

2021年 国家自然科学基金委“优青”

2020年 江苏省“双创团队领军人才”

2019年 国家重点研发计划青年首席，江苏省特聘教授

研究方向为人源化小鼠模型及人类疾病建模

1. 江苏省科技厅，前沿引领技术基础研究重大项目-攀登项目，BK20232018，基于人源化小鼠的复杂类器官在体构建研究，2024-2025，主持；

2. 国家自然科学基金委员会，国家自然科学基金 （优秀青年），32122035，免疫系统人源化小鼠模型，2022-2024，主持；

3. 科技部，国家重点研发计划青年项目，2019YFA0802900，运用人源化小鼠模型解析肠道菌群代谢物调控免疫系统稳态的机理及其在特应性皮炎治疗中的意义，2019-2024，项目首席；

4. 国家自然科学基金委员会，面上项目，32070942，自发特应性皮炎人源化小鼠模型的建立及在抗体免疫治疗的应用，2021-2024，主持；

5. 江苏省组织部，江苏省“双创团队”计划，工程化改造人源化小鼠模型加速肿瘤抗体治疗研发及临床转化，2020-2023，项目首席；

6. 江苏省组织部，江苏省“双创人才”计划，2019-2022；

7.江苏省教育厅，江苏省“特聘教授”，2019-2022；

1. Zheng Liu, Xiang Duan, Yangfang Yun, Siqi Li, Zhiyuan Feng, Jiayin Zhan, Ran Liu, Yan Li*, Jingjing Zhang*. (2023). A photoactivatable Aptamer-Crisper nanodevice enables precise profiling of interferon-gamma release in humanized mice.ACS Nano, doi: 10.1021/acsnano.3c12499.

2. Xiangyu Chen, Jing Zhao, Shuai Yue, Ziyu Li, Xiang Duan, Yao Lin, Yang Yang, Leiqiong Gao, Zhiwei Pan, Xiaofan Yang, Xingxing Su, Min Huang, Xiao Li, Ye Zhao, Xuehui Zhang, Zhirong Li, Li Hu, Jianfang Tang, Yaxing Hao, Qin Tian, Yifei Wang, Lifan Xu, Qizhao Huang, Yingjiao Cao, Yaokai Chen, Bo Zhu, Yan Li, Fan Bai, Guozhong Zhang, Lilin Ye. (2023). Targeting tumor cells toward the antigenic specificity of bystander T cells in tumor microenvironment potentiates cancer immunotherapy. Nature Cancer, Accepted.

3. Deshan Ren, Wei Liu, Shuai Ding, Yan Li*. (2022). Protocol for generating human immune system mice and hydrodynamic injection to modulate human hematopoiesis in vivo, STAR protocols, doi: 10.1016/j.xpro.2022.101217.

4. Xiufei Chen, Wenjie Zhou, Ren-Hua Song, Shuang Liu, Shu Wang, Yujia Chen, Chao Gao, Chenxi He, Jianxiong Xiao, Lei Zhang, Tianxiang Wang, Peng Liu, Kunlong Duan, Chen Zhang, Jinye Zhang, Yiping Sun, Felix Jackson, Fei Lan, Yun Liu, Yanhui Xu, Justin Jong-Leong Wong, Pu Wang, Hui Yang, Yue Xiong, Tong Chen*, Yan Li*, Dan Ye*. (2022). Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity, Science Advances, doi: 10.1126/sciadv.abl5220.

5. Tao Cheng#, Shuai Ding#, Shanshan Liu, Yan Li*, Lingyun Sun* (2021).Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics, doi: 10.7150/thno.48080.

6. Yan Li* and James P. Di Santo. (2019). Modeling infectious diseases in mice with a ‘humanized’ immune system. Microbiology Spectrum, doi：10.1128/ microbiolspec. BAI-0019-2019.

7. Yan Li*, Guillemette Masse Ranson, Zacarias Garcia, Timothee Bruel, Ayrin Kok-Harunova, Helene Strick-Marchand, Gregory Jouvion, Nicolas Serafini, Ai Ing Lim, Mathilde Dusseaux, Thierry Hieu, Frank Bourgade, Antoine Toubert, Daniela Finke, Oliver Schwartz, Phillippe Bousso, Hugo Mouquet and James P. Di Santo. (2018) A human immune system mouse model with robust lymph node development. Nature Methods, doi: 10.1038/s41592-018-0071-6.

8. Yan Li*, Helene Strick-Marchand, Ai Ing Lim, Jiazi Ren, Guillemette Masse-Ranson, Dan Li, Gregory Jouvion, Lars Rogge, Sophie Lucas, Bin Li and James P. Di Santo. (2017) Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Nature Communications, doi: 10.1038/s41467-017-01570-9.

9. Ai Ing Lim, Yan Li, Silvia Lopez-Lastra, Ralph Stadhouders, Franziska Paul, Armanda Cassrouge, Nicolas Serafini, Anne Puel, Laura Surace, Guillemette Masse-Ranson, Helene Strick-Marchand, Lionel Le Bourhis, Roberto Cocchi, Davide Topazio, Paolo Graziano, Lucia Anna Muscarella, Lars Rogge, Jean-Michel Sallenave, Matthieu Allez, Thomas Graf, Rudi W. Hendriks, Jean-Laurent Casanova, Ido Amit, Hans Yssel and James P. Di Santo. (2017) Systemic human ILC precursors provide a substrate for tissue ILC differentiation, Cell, doi: 10.1016/j.cell.2017.02.021.

10. Yan Li*, Jean-Jacques Mention*, Nathalie Court, Antoine Toubert, Hergen Spits, Nicolas Legrand, Erwan Corcuff, Helene Strick-Marchand and James P. Di Santo. (2016) A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development. European Journal of Immunology, doi: 10.1002/eji.201546132.  

11. Yan Li* and James P. DI Santo. (2015) Probing human NK cell biology using Human Immune System (HIS) mice. Current Topics in Microbiology and Immunology. 95:191-208, doi: 10.1007/82_2015_488.

12. Yan Li*, Silvia Lopez-Lastra, Guillemette X. Masse and James P. Di Santo. (2015) NK cell development in human immune system (HIS) mice and their role in HIV pathogenesis. Humanized Mice for HIV Research (Book Chapter), doi: 10.1007/978-1-4939-1655-9_14

13.Yan Li*, Qingfeng Chen*, Dahai Zheng, Lu Yin, Yok Hian Chionh, Lan Hiong Wong, Shu Qi Tan, Thiam Chye Tan, Jerry K. Y. Chan, Sylvie Alonso, Peter C. Dedon, Bing Lim and Jianzhu Chen. (2013) Induction of functional human macrophages from bone marrow promonocytes by M-CSF in humanized mice. Journal of Immunology 191:3192-9, doi: 10.4049/jimmunol.1300742.