2006年-2010年 南京大学化学化工学院  学士

2010年-2016年 南京大学化学化工学院  入选英才计划

2017年-2019年 马鞍山南京大学高新技术研究院 有机合成工程师

2019年-2022年 南京乐透思环保科技有限公司  研发技术支持部总经理

2020年-2022年 南京大学生命科学院  特任助理研究员

2022年-2023年 无锡市南京大学锡山应用生物技术研究所 检测平台技术总监、基建运行部副部长

OLED掺杂材料与ET材料的开发与回收工艺开发； MOCVD前驱体材料的设计与研发，包括高纯硅烷，高纯硼烷的开发与小规模生产；含氟药物中间体开发；铂类抗癌药物的开发；环保新材料新技术开发与应用（螯合剂，絮凝剂，助沉剂）；生物医用材料（抑菌材料）的开发与生产工艺放大开发；小分子荧光探针的设计合成以及生物应用以及实验方法(主要就是流式细胞术和激光共聚焦)探索；基本生物学研究及斑马鱼和小鼠造影方法探究。

[1] Hongxia Xu,‡ Chengcheng Zhu,^‡ Yuncong Chen, Yang Bai, Zhong Han, Shankun Yao, Yang Jiao Hao Yuan Weijiang He * and Zijian Guo *A FRET-based fluorescent Zn²⁺ sensor: 3D ratiometric imaging, flow cytometric tracking and cisplatin-induced Zn²⁺ fluctuation monitoring, Chem.Sci., 2020.11:11037-11041.

[2] Wang, Kun; Zhu, Chengcheng; He, Yafeng, Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion-Targeted Platinum(II) Complex, Angew. Chem. Int. Ed.,2019. 58(14): p. 4638-4643.

[3] Zhu, Chengcheng, Wang, Mengjia, Qiu, Lin, Hao, Shuangying, Li, Kuanyu, Guo, Zijian^*, He, Weijiang^*, A mitochondria-targeting fluorescent Fe³⁺ probe and its application in Cheek for labile Fe³⁺ monitoring via imaging and flow cytometry, Dyes Pigments, 2018. 157: p. 328-333.

[4] Zhang, Zhenqin, Zhu, Zhenzhu, Luo, Cheng, Zhu, Chengcheng, Zhang, Changli, Guo, Zijian^*, Wang, Xiaoyong^* A Potential Bone-Targeting Hypotoxic Platinum(II) Complex with an Unusual Cytostatic Mechanism toward Osteosarcoma Cells Inorg. Chem., 2018. 57(6): p. 3315-3322.

[5] Bai, Yang, Shi, Xiangchao, Chen, Yuncong, Zhu, Chengcheng, Jiao, Yang, Han, Zhong, He, Weijiang^*, Guo, Zijian^*, Coumarin/BODIPY Hybridisation for Ratiometric Sensing of Intracellular Polarity Oscillation, Chem-Eur J, 2018. 24(29): p. 7513-7524.

[6] Zhang, Zhenqin, Wang, Xiaoyong, Luo, Cheng, Zhu, Chengcheng, Wang, Kun, Zhang, Changli, Guo, Zijian^*, Dinuclear Platinum(II) Complexes with Bone-Targeting Groups as Potential Anti-Osteosarcoma Agents. Chem- Asian J, 2017. 12(13): p. 1659-1667.

[7] Xue, Xuling, Zhu, Chengcheng, Chen, Huachao, Bai, Yang, Shi, Xiangchao, Jiao, Yang, Chen, Zhongyan, Miao, Yupeng, He, Weijiang^* and Guo, Zijian^*., A New Approach to Sensitize Antitumor Monofunctional Platinum(II) Complexes via Short Time Photo-Irradiation. Inorg. Chem, 2017. 56(7): p. 3754-3762.

[8] Muhammad, Nafees, Sadia, Nasreen, Zhu, Chengcheng, Luo, Cheng, Guo, Zijian^* and Wang, Xiaoyong^*., Biotin-tagged platinum(IV) complexes as targeted cytostatic agents against breast cancer cells. Chem.Commun, 2017. 53(72): p. 9971-9974.

[9] Zhu, Zhenzhu, Wang, Zenghui, Hao, Yigang, Zhu, Chengcheng, Jiao, Yang, Chen, Huachao, Wang, Yun-Ming, Yan, Jun, Guo, Zijian^*. and Wang, Xiaoyong^*.., Glutathione boosting the cytotoxicity of a magnetic platinum(IV) nano-prodrug in tumor cells. Chem. Sci, 2016. 7(4): p. 2864-2869.

[10] Xue, Xuling, Fang, Hongbao, Chen, Huachao, Zhang, Changli, Zhu, Chengcheng, Bai, Yang, He, Weijiang^*. and Guo, Zijian^*., In vivo fluorescence imaging for Cu²⁺ in live mice by a new NIR fluorescent sensor. Dyes Pigments, 2016. 130: p. 116-121.

[11] Muhammad, Nafees, Wang, Xiaoyong, Wang, Kun, Zhu, Chengcheng, Zhu, Zhenzhu, Jiao, Yang and Guo, Zijian^*, Dual-drug loaded nanoformulation with a galactosamine homing moiety for liver-targeted anticancer therapy. Dalton T, 2016. 45(33): p. 13169-13178.

[12] Yuncong Chen, Chengcheng Zhu, Jiajie Cen, Yang Bai, Weijiang He^*, and Zijian Guo^*，Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor，Chem.Sci., 2015, 6, 3187;

[13] Wen Zhou, Xiaoyong Wang^*, Ming Hu, Chengcheng Zhu and Zijian Guo^*, A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action, Chem.Sci., 2014, 5, 2761;

[14]Shangnong Wu, Xiaoyong Wang ^*, Yafeng He, Zhenzhu Zhu, Chengcheng Zhu, Zijian Guo ^*, A monofunctional trinuclear platinum complex with steric hindrance demonstrates strong cytotoxicity against tumor cells, J. Inorg. Biochem.,2014, 139, 77-84;

[15] Lin Qiu, Chengcheng Zhu, Huachao Chen, Ming Hu, Weijiang He^*, and Zijian Guo^*, A turn-on fluorescent Fe³⁺ sensor derived from an anthracene-bearing bisdiene macrocycle and its intracellular imaging application, Chem. Commun., 2014, 50, 4631;

[16] Yuncong Chen, Chengcheng Zhu, Weijiang He^*, and Zijian Guo^*, A novel ratiometric fluorescent probe for Hg²⁺imaging in biological system, Science China Chemisity, 2014, 44, 631;

[17] Lin Qiu, Ji Yi-Fan, Chengcheng Zhu, Yuncong Chen, Weijiang He^*, and Zijian Guo^*, A BODIPY-derived Zn²⁺ fluorescent sensor: the enhanced ICT effect, Chinese J Inorg. Chem., 2014, 30, 169-178;

[18] Lian Zhou, Chengcheng Zhu, Yun-Shan Xue, Weijiang He ^*, Hong-Bin Du ^*, Xiao-Zeng You ^*, Yi-Zhi Li, Two fluorescent 2,6-substituted pyridyl boron-dipyrromethene dyes for selective sensing of cuprous ions, Inorg. Chem. Commun., 2013, 35, 355-359;

[19] Jinzhuan Wang, Xiaoyong Wang ^*, Yajie Song, Chengcheng Zhu, Jing Wang, W Kun ang, Zijian Guo ^*, Detecting and delivering platinum anticancer drugs using fluorescent maghemite nanoparticles, Chem. Commun., 2013, 49, 2786.

[20] Yuncong Chen, Chengcheng Zhu, Zhenghao Yang, Junjie Chen, Yafeng He, Yang Jiao, Weijiang He^*, Qiu Lin, Cen Jiajie, Guo Zijian^*，A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria, Angew. Chem. Int. Ed., 2013, 52, 1688-1691.

[21] Yuncong Chen, Chengcheng Zhu, Cen Jiajie, Li Jing, Weijiang He^*, Jiao Yang, Guo Zijian^*，A reversible ratiometric sensor for intracellular Cu²⁺ imaging: metal coordination-altered FRET in a dual fluorophore hybrid, Chem. Commun., 2013, 49, 7632.

[22] Li Jing, Chengcheng Zhu, Weijiang He^*，A Turn-on pH Fluorescent Probe Based on NBD-NH₂  Fluorophore and Its pHi Imaging Application, Chinese J Inorg. Chem., 2013, 29, 2528-2534.

[23] Yong Fu, Zhitao Xing, Chengcheng Zhu, Hongwei Yang, Weijiang He^*, Chengjian Zhu ^*, Yixiang Cheng ^*, A novel calixsalen macrocycle: metal sensing behavior for Zn²⁺ and intracellular imaging application, Tetrahedron Lett., 2012, 53, 804-807.

[24]Yuncong Chen, Chengcheng Zhu, Yang Zhenghao, Li jing, Weijiang He^*, Qiu Lin, Chen junjie, Guo Zijian^*，A new “turn-on” chemodosimeter for Hg²⁺: ICT fluorophore formation via Hg²⁺-induced carbaldehyde recovery from 1,3-dithiane, Chem. Commun., 2012, 48, 5094.

[25] Shengde Wu ^#, Chengcheng Zhu^#, Changli Zhang, Zhen Yu, Weijiang He^*, Yafeng He, Yizhi Li, Jing Wang, Guo Zijian^*, In Vitro and in Vivo Fluorescent Imaging of a Monofunctional Chelated Platinum Complex Excitable Using Visible Light, Inorg. Chem., 2011, 50, 11847-11849.

[26] Shengde Wu, Xiaoyong Wang^*, Chengcheng Zhu, Yajie Song, Jing Wang, Yizhi Lia and Zijian Guo^*, Monofunctional platinum complexes containing a 4-nitrobenzo-2-oxa-1,3-diazole fluorophore: Distribution in tumour cells, Dalton T., 2011.40, 10376-10382.

[27] Zhenghao Yang, Chongchong Yan, Yuncong Chen, Chengcheng Zhu, Changli Zhang, Xindian Dong, Weiqi Yang, Zijian Guo, ^* Yi Lu^* and weijiang He^*, A novel terpyridine/benzofurazan hybrid fluorophore: metal sensing behavior and application, Dalton T., 2010, 40, 2173-2176.

已申请专利：

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